The fat lady is singing at Sears Holdings Corp.

The long-struggling retailer said on Tuesday that there was “substantial doubt” that it could stay in business.

“Our historical operating results indicate substantial doubt exists related to the company’s ability to continue as a going concern,” Sears said in a filing with the Securities and Exchange Commission. In the filing, its annual report for the period ended January 28, 2017, Sears reported a $2.2 billion loss for the year. Its long-term debt as of January totaled nearly $4.2 billion,

In the report, the retailer cited its efforts to cut costs, sell property, tap new funding sources and make other moves to lessen the continuing flow of red ink. But with revenue…