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Many local shopping malls are going to have to grapple with the loss of one more retailer: Gymboree.

The San Francisco-based children’s clothing chain is closing nearly a fourth, or 350, of its stores nationwide, including four Gymboree stores in the Twin Cities — at Southdale Center, Burnsville Center, Eden Prairie Center, and the Shoppes at Arbor Lake in Maple Grove. The company is also closing two Crazy 8 stores at Burnsville Center and in Woodbury.

Outside the metro area, Gymboree is also closing stores in Mankato and Medford.

The closing sales are expected to begin Tuesday.

Gymboree, which filed for bankruptcy protection last month, is one of the latest casualties of massive disruption sweeping across retail as a number of brands are struggling with large debt loads as well as lower mall traffic and the shift to online shopping. Other chains that have recently filed for bankruptcy include Payless ShoeSource, Aeropostale, PacSun, Gordmans, Rue21, BCBG, Wet Seal, The Limited and True Religion. Others that are on analysts’ watch lists of who could be next include Claire’s and J. Crew.

The latest development with Gymboree…